Tuilleadh fiosrachaidh ― Scots gaelic

Is e suidheachadh craiceann maireannach a th’ ann an Prurigo nodularis air a chomharrachadh le grunn chnapan làidir agus nodules, mar as trice a lorgar air pàirtean a-muigh nan gàirdeanan is na casan. Faodaidh na cnapan sin a bhith eadar-dhealaichte ann an dath bho fheòil gu pinc agus tha iad gu math tachaiseach. Faodaidh iad buaidh a thoirt air daoine aig aois sam bith agus gu tric bidh iad ceangailte ri suidheachaidhean craiceann eile a dh’ adhbhraicheas tachas leantainneach, leithid dermatitis atopic. Tha roghainnean làimhseachaidh a’ toirt a-steach cungaidhean làidir an-aghaidh itch, drogaichean a bheir buaidh air an t-siostam dìon, agus cungaidhean-leigheis a tha ag amas air an t-siostam nearbhach. Mar as trice bidh làimhseachadh prurigo nodularis a’ toirt a-steach leigheas fad-ùine.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.

Mar as trice bidh làimhseachadh a’ toirt a-steach a bhith a’ cleachdadh uachdaran no in-stealladh steroids air an raon air a bheil buaidh. Ann an cùisean nas cruaidhe no nas cruaidhe, dh'fhaodadh gum bi feum air leigheasan mar leigheas aotrom no cungaidhean-leigheis a chuireas bacadh air an t-siostam dìon. Tha Thalidomide agus lenalidomide nan roghainnean airson fìor chùisean, ach faodaidh droch bhuaidhean a bhith aca. Tha leigheasan nas ùire (opioid receptor antagonists, neurokinin-1 receptor antagonists) a’ nochdadh gealladh ann a bhith a’ làimhseachadh prurigo nodularis le nas lugha de bhuaidhean taobh an coimeas ri thalidomide no lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.

Is e suidheachadh craiceann a th’ ann an Chronic prurigo a tha air a chomharrachadh le tachas fad-ùine (mairidh e còrr air 6 seachdainean) , lotan craiceann co-cheangailte ri sgrìobadh, agus eachdraidh de sgrìobadh tric. Tha e a’ toirt a-steach neuroinflammation agus fibrosis sa chraiceann.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.

Tha Prurigo nodularis na dhuilgheadas craiceann maireannach air a chomharrachadh le nodules tachaiseach. Chan eil fios againn dè dìreach a tha ga adhbharachadh, ach tha e coltach gu bheil pàirt aig cùisean dìonachd is nearbhach anns a’ chearcall sgrìobadh itch-scratch. An-dràsta, chan eil làimhseachadh sam bith air aontachadh le FDA na SA gu sònraichte airson prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.